第一部神盾局电影，故事基于漫画，西崔克尔男爵挂了之后，其女儿蛇神夫人卷土重来，偷了某种大规模杀伤性武器威胁全城，于是神盾局请出已经退休的尼克·弗瑞重新出马，阻止危机什么的，都是很老套的东西。
Marvel's hard-boiled hero is brought to TV. He is brought back to fight the menace of Hydra after exiling himself in the Yukon since the end of the Cold War. The children of the former Hydra head, Baron Von Stucker, have taken charge of the terrorist organization. Under the lead of his vicious daughter, Viper, Hydra has seized a deadly virus and threatens the destruction of America. The covert agency SHIELD brings Fury out of retirement to fight the terrorists.展开