The New Adventures of Old Christine 第五季也是最后一季于 2009 年 9 月 23 日首播，并于 2010 年 5 月 12 日完结，共 21 集。在这一季中，芭芭被捕后，她被克里斯汀、马修和新男友戴夫救出。当理查德试图赢回新克里斯汀时，他和马修暂时搬进了新公寓。 Christine 开始接受治疗，但她被她的治疗师 Max 所吸引。他们最终放弃了克里斯汀的治疗，转而建立了关系。新克里斯汀宣布她怀孕了，这让理查德与她重新建立了关系，新克里斯汀最终生下了一个女婴。与此同时，巴伯与不情愿的戴夫订婚。在本季结束时，克里斯汀也与马克斯订婚，但她对他受过良好教育的朋友感到害怕，因此她决定重返大学。本季获得了两项艾美奖提名：一项是为路易达孚 (Louis-Dreyfus) 提供的喜剧系列杰出女主角提名，另一项是为多机位系列获得的杰出艺术指导。

  The fifth and final season of The New Adventures of Old Christine premiered on September 23, 2009 and concluded on May 12, 2010. It's consisted of 21 episodes. In this season, following Barb's arrest she is rescued by Christine, Matthew and new boyfriend Dave. While Richard tries to win New Christine back, he temporarily moves into a new apartment with Matthew. Christine begins going to therapy, but she is attracted to her therapist, Max. They eventually abandon Christine's therapy and strike up a relationship instead. New Christine announces that she is pregnant, causing Richard to rekindle his relationship with her and New Christine eventually gives birth to a baby girl. Meanwhile, Barb becomes engaged to a reluctant Dave. At the conclusion of the season, Christine also becomes engaged to Max, but she feels intimidated by his very educated friends so she decides to return to college. This season earned two Emmy Award nominations: one for Outstanding Lead Actress in a Comedy Series for Louis-Dreyfus, and one for Outstanding Art Direction for a Multi-Camera Series。